Solitary Extramedullary Plasmacytoma of Breast- A Rare Case Report

 Solitary Extramedullary Plasmacytoma of Breast- A Rare Case Report

Ramanan, Ramchandar, G.Suresh, A. Sureshkumar and Siva Kaarthikeyan. “Solitary Extramedullary Plasmacytoma of Breast- A Rare Case Report.” J Surg 18 (2022): 019.

Abstract

Background: Extramedullary plasmacytoma accounts for less than 5% of plasma cell neoplasm. Primary breast plasmacytoma is extremely rare condition encountered

in clinical practice without any bone marrow involvement or as secondary from multiple myeloma. It can mimic various benign and malignant lesions in the breast hence it

should be kept in differential diagnosis as management would completely differ. Meticulous approach is needed in evaluation like CT scan of upper airway, Histopathological

examination, Bone marrow biopsy, emphasizing the importance of each in arriving at a diagnosis. The incidence of breast plasmacytoma is very rare accounting to less

than 5% in which only 15-16 cases of solitary breast plasmacytoma have been reported over the last 80 years and hence there is a lack of standard clinical or radiological

criteria criteria in the diagnosis and management of breast plasmacytoma. In this study we report solitary extramedullary plasmacytoma of left breast in 70-year-old women

with meticulous stepwise approach.

Keywords: Plasmacytoma of breast • Chemotherapy • Radiotherapy • Bone marrow examination

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Clinical Features of COVID-19 and Malaria Coinfection Based on Two Cases in Central African Republic

Clinical Features of COVID-19 and Malaria Coinfection Based on Two Cases in Central African Republic

Sekulic, Igor, Jelena Boskovic Sekulic, Vojislav Alempijevic and Nemanja Rancic, et al. "Clinical Features of COVID-19 and Malaria Coinfection Based on Two Cases in Central African Republic." Malar Contr Elimination 11 (2022): 188.

Abstract

The aim of this manuscript is to bring our experience from Central African Republic (CAR), an endemic malarial area, during the COVID-19

pandemic. We present two cases treated at MINUSCA level 2+ hospital in Bangui, central African republic, during December 2021 and

January 2022. COVID-19 and malaria infection were confirmed by appropriate tests. First case is man, 36 years old, who came to

hospital, complaining about muscle pain, headache and fiver. Second case is a man, 41 years old, who came to hospital due to fiver,

caught and malaise. Symptoms started to appear a day ago. We can conclude that in malaria endemic areas, in light of

existing COVID-19 pandemia, based on similar symptoms characteristic of both diseases, it is essential to suspect both diseases and

keep in mind the possibility of coinfection. Therefore a patient with uncharacteristic infectious symptoms should be tested for

malaria, so as well for COVID-19 infection.

Keywords: Headache • World Health Organization (WHO) • COVID 19 • Coughing

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The Development and Evaluation of a Lightweight Underactuated RACA Hand Exoskeleton for Neurorehabilitation

 The Development and Evaluation of a Lightweight Underactuated RACA Hand Exoskeleton for Neurorehabilitation

Batra, Haroon, Laurel Blau and Davina Hoffmann. “The Development and Evaluation of a Lightweight Underactuated RACA Hand Exoskeleton for Neurorehabilitation.” J Trauma Treat 11 (2022): 542.

Abstract

The growing use of automated devices in neuro-recovery treatments necessitates the availability of lightweight, simple-to-use, smart, and

adaptable frameworks. RobHand was designed with these goals in mind. It is a hand exoskeleton that is especially suitable for individuals who

have finger spasticity since it is simple to insert and allows both bending and expansion of the fingers from an underactuated position. The primary

attributes, mechanical plan, and turn of events, as well as approval of the kinematic model of the device, are introduced in this work, which has

been completed in accordance with the proposals of the new IEC 80601-2-78 norm, which formalises the concept of RACA (Recovery, Evaluation,

Remuneration, Easing) robot and addresses parts of productivity and wellbeing.

Keywords: Exoskeleton • Stroke rehabilitation • Underactuated mechanisms

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The Impact of Photobiomodulation for Oral Mucositis on the Quality of Life of Head and Neck Cancer patients undergoing Radio Chemotherapy

The Impact of Photobiomodulation for Oral Mucositis on the Quality of Life of Head and Neck Cancer patients undergoing Radio Chemotherapy

Passos Nathália M,Costa Agda S, Dantas Juliana B. L., Martins Gabriela B., Lima Hayana R., Medrado Alena R. A. P., Carrera Manoela. "The Impact of Photobiomodulation for Oral Mucositis on the Quality of Life of Head and Neck Cancer patients undergoing Radio Chemotherapy." J integr oncol 11 (2022) : 397

Abstract

Background: Photobiomodulation (PBM) has been used to prevent and manage Oral Mucositis (OM) due to its bio stimulating properties.

We evaluated the impact of PBM for OM on the Quality of Life (QOL) of Head and Neck (HNC) patients undergoing radio-chemotherapy.

Methods: Patients were allocated randomly to the Laser (LO) and Control Group (LS). PBM was used three times a week. QoL assessment

were undertaken at the 1st, 6th, 12th, 18th, and 24th radiotherapy sessions.

Results: The overall QOL scores decreased in both groups. A comparative analysis between the LO and LS groups demonstrated a worsening

over time in the saliva, taste, swallowing, and recreation domains (p<0,05). The LS group demonstrated a greater impairment of QOL in

chewing at the 1st (p= 0.011), 18th (p= 0.023) and 24th sessions (p= 0.012).

Conclusion: PBM prevented the manifestation of more severe OM degrees, improving the QOL at oral related domains.

Keywords: Low Level Laser Therapy • Oral mucositis; Head and neck cancer • Radiotherapy • Quality of Life

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Analytical and Clinical Validation of a Novel Blood- Based Biomarker of Liver Transplant Rejection

 Analytical and Clinical Validation of a Novel Blood- Based Biomarker of Liver Transplant Rejection

Weems JC, Pierry D, Holman J, Kandpal M, Kurian SM, Meintjes P, Beswick N, and Levitsky J. "Analytical and Clinical Validation of a Novel Blood-Based Biomarker of Liver Transplant Rejection." J Transplant Technol Res 11 (2021): 180.

Abstract

Background: We have discovered and validated a microarray-based test that analyzes blood gene expression profiles (GEP) as an indicator of immune status in liver

transplant recipients with stable liver function.

Methods: Analytical performance studies to characterize stability of RNA in blood during collection and shipment, analytical sensitivity (input RNA concentration),

analytical specificity (interfering substances) and assay performance (clinical validity, and intra-assay, inter-assay, inter- laboratory reproducibility).

Results: Total RNA extracted from whole blood specimens collected in PAXgene Blood RNA tubes was stable up to 3 days at room temperature (stable RNA yield).

Under routine ambient shipping conditions, storage and shipping temperatures did not affect results. However, specimen shipments exposed to temperatures >400°C

or to ambient temperatures for >3 days were unacceptable for processing. Analytical sensitivity studies demonstrated tolerance to variation in RNA input (50 to 400

ng per 3’ IVT (in vitro transcript] labeling reaction). Specificity studies using genomic Jurkat DNA spiked into 3 ’IVT reactions at 10-20% demonstrated negligible assay

interference. The test was reproducible across operators, runs, reagent lots, and laboratories. External validation demonstrated that the TruGraf Liver blood test

accurately classified patients in 84% of 155 samples.

Conclusions: The previously published biomarker is the first non-invasive test to be demonstrated to have clinical utility in assessing immune status of LT recipients

with stable liver function and shows promise as a reasonable and necessary tool supporting personalizing immunosuppressive therapy.

Keywords: Liver transplant recipients • Gene expression signatures• Immunosuppression • TruGraf blood test

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